Ellie Goulding - Beating Heart (Official Video)
MC HAUGH Background The efficacy of thrombolytic therapy for acute myocardial infarction depends partly on how soon after the onset of symptoms it is administered. We therefore studied the efficacy and safety of thrombolytic therapy administered before hospital admission and thrombolytic therapy administered after admission in patients with suspected myocardial infarction.
Methods In a multicenter, double-blind study, patients seen within six hours of the onset of symptoms who had a qualifying lead electrocardiogram were randomly assigned to receive either anistreplase before admission, followed by placebo in the hospital prehospital groupor placebo before admission, followed by single thump in chest in the hospital hospital group.
Prehospital therapy was administered by emergency medical personnel. Results A total of patients were randomly assigned to the prehospital group, and to the hospital group.
The patients in the prehospital group received thrombolytic therapy a median of 55 minutes earlier than those in the hospital group. We observed a nonsignificant reduction in overall mortality at 30 days in the prehospital group 9.
Death from cardiac causes was significantly less frequent in the prehospital group than in the hospital group 8. With the exception of symptomatic hypotension, however, the overall incidence of these events was similar for both groups.
Conclusions Prehospital single thump in chest therapy for patients with suspected myocardial infarction is both feasible and safe when administered by well-equipped, well-trained mobile emergency medical staff.
Although such therapy appears to reduce mortality from cardiac causes, our data do not definitely establish that it reduces overall mortality.